CYP2D6 copy number distribution in the US population
Recently published in Pharmacogenetics and Genomics, the attached article reviews the clinical experience with CYP2D6 mutation rates in a random subset of patients. The reseach points to substantial variation in 2D6 mutations by race. Surprisingly, they found that 20% of African Americans may have aberrant 2D6 activity and as many as 1:300 may be completely missing copies of this gene. 70% of this same group were on a drug metabolized by 2D6.
Pharmacogenetic and Genomics article
This data point underscores the value of pharmacogenetic testing based on personal genetic variation.
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